Methylamine → HCID 178464551, compound

HRID 1492239Notes

Reaction equation

HRID 1492239 reaction equation
I.CS[C:4](=[N:18][CH2:19][CH3:20])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[CH3:21][NH2:22]>C(O)C>[CH2:19]([NH:18][C:4]([NH:22][CH3:21])=[N:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)[CH3:20]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 18952330HCID 18952330, compound

Product 1

HCID 178464551HCID 178464551, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
45 °C

Procedure

A mixture of 2-methyl-3-ethyl-1-(2-morpholinophenyl)-2-thiopseudourea hydroiodide (6 g) and 33% methylamine in absolute ethanol solution (250 ml) was heated initially for 24 hours at 45° C. and then left at room temperature for 14 days to yield 1-ethyl-2-(2-morpholinophenyl)-3-methylguanidine as a colourless solid (m.p. 118°-119° C.) which was recrystallised from hexane.

Sources & evidence

ORD record
ord-2891a53ae8454b7ebbff41aecb70e14e
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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