Ethanol → HCID 178426250, compound

HRID 1492259Notes

Reaction equation

HRID 1492259 reaction equation
I.CS[C:4](=NC)[NH:5][C:6]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:7]=1[N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.[OH:21][CH2:22][CH2:23][NH:24][CH2:25][CH2:26][NH2:27].C(O)C.[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35]>CO>[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35].[OH:21][CH2:22][CH2:23][N:24]1[CH2:25][CH2:26][NH:27][C:4]1=[N:5][C:6]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:7]=1[N:13]1[CH2:14][CH2:15][O:16][CH2:17][CH2:18]1.[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35].[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35].[OH:21][CH2:22][CH2:23][N:24]1[CH2:25][CH2:26][NH:27][C:4]1=[N:5][C:6]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:7]=1[N:13]1[CH2:14][CH2:15][O:16][CH2:17][CH2:18]1

Participants

6

Reactant 4

HCID 702EthanolHCID 8112N-(2-Hydroxyethyl)ethylenediamineHCID 444972Fumaric AcidHCID 18952165HCID 18952165, compound

Product 1

HCID 178426250HCID 178426250, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-methyl-1-(5-methyl-2-morpholinophenyl)-3-methyl-2-thiopseudourea hydroiodide (8.4 g prepared as described in Example 227), N-(2-hydroxyethyl)ethylenediamine (6.8 ml) and ethanol (80 ml)) was heated under reflux for 30 hours to give an oil which was treated with fumaric acid in methanol to give 4-{2-[1-(2-hydroxyethyl)-2-imidazolidinylideneamino]-4-methylphenyl}morpholine sesquifumarate (m.p. 135°-136° C.).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 30 hours
  3. customto give an oil which

Sources & evidence

ORD record
ord-05de5f274f0e4bf2af42489cf9c3756c
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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