反应详情

The procedure of Example 4a) was also used to introduce the 3-trifluoromethyl phenoxy group by reaction of 2-benzyloxy-6-chloropyridine (5 g; 23 mmols) from a) above with 3-trifluoromethylphenol (3.3 g; 0.018 mols) using dry sodium hydride (0.55 g) and dry dimethylformamide (200 ml) as solvent, with a 1 hour reflux stage. 2-(3-Trifluoromethylphenoxy)-6-benzyloxypyridine (4.9 g; 51%) was obtained as a yellow oil following solvent extraction (chloroform/water--500 ml; 50/50), and chromatography plus distillation of the organic layer.

1. additionto introduce the 3-trifluoromethyl phenoxy group
2. temperaturewith a 1 hour reflux stage