1-Hydroxypiperidine → 1,8-Diazabicyclo(5.4.0)undec-7-ene

HRID 1492404Notes

Reaction equation

HRID 1492404 reaction equation
[N:1]1(O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[N:9]1[C:13](=[O:14])[CH2:12][CH2:11][C:10]1=O>>[N:9]12[CH2:10][CH2:11][CH2:12][N:1]=[C:6]1[CH2:5][CH2:4][CH2:3][CH2:2][CH2:13]2.[NH:1]1[CH2:6][CH2:5][CH:4]([OH:14])[CH:3]=[CH:2]1

Participants

4

Reactant 2

HCID 209351-HydroxypiperidineHCID 31398Chlorosuccinimide

Product 2

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 18950548HCID 18950548, compound

Procedure

reacting the piperidinol first with N-chlorosuccinimide and then with 1,8-diazabicyclo[5.4.0]undec-7-ene to give the corresponding 1,4,5,6-tetrahydro-4-pyridinol; and,

Sources & evidence

ORD record
ord-74e5f553f93246dbba696b0e4685d944
Source dataset
uspto-grants-1994_12
Patent number
US05374632

Reaction notes

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