Sulfuric Acid → HCID 18950756, compound

HRID 1492535Notes

Reaction equation

HRID 1492535 reaction equation
C([NH:3][CH:4]([C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1)[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C:13]([O:15][CH3:16])=[O:14])=[CH:8][CH:7]=1)=O.S(=O)(=O)(O)O.[Cl-].[Na+]>C(OCC)(=O)C>[NH2:3][CH:4]([C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1)[CH2:5][C:6]1[CH:7]=[CH:8][C:9]([CH2:12][C:13]([O:15][CH3:16])=[O:14])=[CH:10][CH:11]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 5234Sodium ChlorideHCID 18950680HCID 18950680, compound

Product 1

HCID 18950756HCID 18950756, compoundYield 31.9%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Conditions

Temperature
60 °C

Procedure

To 0.38 g of methyl 4-[2-formamido-2-(3-pyridyl)ethyl]phenylacetate in 10 ml of methanol-1,4 dioxane (1:1) in solution was added 5 ml of 4% sulfuric acid, and stirred under heating at 60° C. for one hour, which was then poured into saturated aqueous sodium chloride solution for extraction with ethyl acetate. The ethyl acetate phase obtained was washed in saturated aqueous sodium chloride solution and dried over magnesium sulfate, followed by distillation of the solvent, to produce 0.11 g of methyl 4-[2-amino-2-(3-pyridyl)ethyl]phenylacetate.

Workup

  1. washwas washed in saturated aqueous sodium chloride solution
  2. dry with materialdried over magnesium sulfate
  3. distillationfollowed by distillation of the solvent

Sources & evidence

ORD record
ord-f1e7fdc7ef7c43d69c026ac43e57c135
Source dataset
uspto-grants-1994_12
Patent number
US05374641

Reaction notes

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