Hydrochloric Acid → HCID 15232189, compound

HRID 1492537Notes

Reaction equation

HRID 1492537 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH:12]([C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)[CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:21]([O:23]C)=[O:22])=[CH:16][CH:15]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[OH-].[Na+].Cl>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:11][CH:12]([C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)[CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:21]([OH:23])=[O:22])=[CH:16][CH:15]=2)(=[O:9])=[O:10])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15232188HCID 15232188, compound

Product 1

HCID 15232189HCID 15232189, compoundYield 84.3%

Procedure

To 0.06 g of methyl 4-[2-(4-chlorobenzenesulfonamido)-2-(3-pyridyl)ethyl]phenylacetate in 10 ml of methanol-1,4 dioxane (1:1) solution was added 2 ml of aqueous 2N sodium hydroxide solution, and stirred overnight at room temperature. After completion of reaction, the solution was neutralized with 2 ml of 2N hydrogen chloride. The crystalline deposited was filtered to produce 49 mg of 4-[2-(4-chlorobenzenesulfonamido)-2-(3-pyridyl)ethyl]phenylacetic acid. The spectrometric data thereof supports the structure of [29] as follows.

Workup

  1. customAfter completion of reaction
  2. filtrationThe crystalline deposited was filtered

Sources & evidence

ORD record
ord-e9e65b18464249419671cc58cc698baf
Source dataset
uspto-grants-1994_12
Patent number
US05374641

Reaction notes

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