Hydrochloric Acid → HCID 18950749, compound

HRID 1492554Notes

Reaction equation

HRID 1492554 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH:12]([C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)[CH2:13][CH2:14][C:15]2[CH:24]=[CH:23][C:18]([C:19]([O:21]C)=[O:20])=[CH:17][CH:16]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[OH-].[Na+].Cl>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:11][CH:12]([C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)[CH2:13][CH2:14][C:15]2[CH:24]=[CH:23][C:18]([C:19]([OH:21])=[O:20])=[CH:17][CH:16]=2)(=[O:9])=[O:10])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18950689HCID 18950689, compound

Product 1

HCID 18950749HCID 18950749, compoundYield 53.1%

Procedure

To 20 ml of the solution of 0.14 g of methyl 4-[3-(4-chlorobenzenesulfonamido)-3-(3-pyridyl)propyl}benzoate in methanol-1,4 dioxane (1:1) was added 5 ml of aqueous 2N sodium hydroxide solution, and stirred at room temperature overnight. After completion of the reaction followed by neutralization with 5 ml of 2N hydrogen chloride, the crystalline deposited was filtered to obtain 72 mg of 4-[3-(4-chlorobenzenesulfonamido)-3-(3-pyridyl)propyl]benzoic acid. The spectrometric data supports the structure of [37] as follows.

Workup

  1. filtrationthe crystalline deposited was filtered

Sources & evidence

ORD record
ord-4840592a95964d198afc02d79731d5a7
Source dataset
uspto-grants-1994_12
Patent number
US05374641

Reaction notes

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