Trifluoroacetic acid → HCID 19385695, compound

HRID 1492634Notes

Reaction equation

HRID 1492634 reaction equation
[C:1]([CH:8]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][N:17]2[C:21]3=[N:22][C:23]([C:27]([O:29][CH3:30])=[O:28])=[CH:24][C:25]([CH3:26])=[C:20]3[N:19]=[C:18]2[CH2:31][CH3:32])=[CH:12][C:11]=1[CH2:33][CH2:34][CH3:35])([O:3]C(C)(C)C)=[O:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:1]([CH:8]([C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)[O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][N:17]2[C:21]3=[N:22][C:23]([C:27]([O:29][CH3:30])=[O:28])=[CH:24][C:25]([CH3:26])=[C:20]3[N:19]=[C:18]2[CH2:31][CH3:32])=[CH:12][C:11]=1[CH2:33][CH2:34][CH3:35])([OH:3])=[O:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 19385639HCID 19385639, compound

Product 1

HCID 19385695HCID 19385695, compoundYield 57.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 21.4 mg (0.038 mmol) of the product of Step P in CH2Cl2 (1 mL) was added TFA (0.4 mL, 5.19 mmol) at rt. The solution was stirred at rt for 2 hours. The crude mixture was directly purified by flash chromatography eluted with CHCl3 /MeOH/NH4OH (100:10:1) to give 11 mg of the title compound as a white solid.

Workup

  1. customThe crude mixture was directly purified by flash chromatography
  2. washeluted with CHCl3 /MeOH/NH4OH (100:10:1)

Sources & evidence

ORD record
ord-67e426667b6441ce9acf343579e981f7
Source dataset
uspto-grants-1994_12
Patent number
US05374638

Reaction notes

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