HRID1492634

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CCCc1cc(Cn2c(CC)nc3c(C)cc(C(=O)OC)nc32)ccc1OC(C(=O)OC(C)(C)C)c1ccccc1

HCID19385639

未命名化合物

PRODUCTS

生成物

结构：CCCc1cc(Cn2c(CC)nc3c(C)cc(C(=O)OC)nc32)ccc1OC(C(=O)O)c1ccccc1

HCID19385695

未命名化合物

收率 57.7%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of 21.4 mg (0.038 mmol) of the product of Step P in CH2Cl2 (1 mL) was added TFA (0.4 mL, 5.19 mmol) at rt. The solution was stirred at rt for 2 hours. The crude mixture was directly purified by flash chromatography eluted with CHCl3 /MeOH/NH4OH (100:10:1) to give 11 mg of the title compound as a white solid.

WORKUP

后处理

customThe crude mixture was directly purified by flash chromatography
washeluted with CHCl3 /MeOH/NH4OH (100:10:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-67e426667b6441ce9acf343579e981f7
来源数据集: uspto-grants-1994_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05374638
来源说明: uspto-grants-1994_12

反应 SMILES

[C:1]([CH:8]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][N:17]2[C:21]3=[N:22][C:23]([C:27]([O:29][CH3:30])=[O:28])=[CH:24][C:25]([CH3:26])=[C:20]3[N:19]=[C:18]2[CH2:31][CH3:32])=[CH:12][C:11]=1[CH2:33][CH2:34][CH3:35])([O:3]C(C)(C)C)=[O:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:1]([CH:8]([C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)[O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][N:17]2[C:21]3=[N:22][C:23]([C:27]([O:29][CH3:30])=[O:28])=[CH:24][C:25]([CH3:26])=[C:20]3[N:19]=[C:18]2[CH2:31][CH3:32])=[CH:12][C:11]=1[CH2:33][CH2:34][CH3:35])([OH:3])=[O:2]