反应详情

温度

80 °C

To 100 ml of an aqueous solution containing 5.0 g of ammonium chloride were added 98.0 g of N-(2-cyclohexyloxy-5-nitrophenyl)methanesulfonamide and 78.0 g of an iron powder with heating at 80° C. with stirring, followed by stirring for 2 hours. The reaction solution was cooled back to room temperature, and then ethyl acetate and water were added thereto. After extraction, the organic layer was successively washed with water and a saturated aqueous sodium chloride solution, and dried over anhydrous magnesium sulfate. After evaporation of the solvent, the residue was recrystallized from ethanol to give 71.7 g of N-(5-amino-2-cyclohexyloxyphenyl)methanesulfonamide as colorless prisms.

1. stirringby stirring for 2 hours
2. temperatureThe reaction solution was cooled back to room temperature
3. extractionAfter extraction
4. washthe organic layer was successively washed with water
5. dry with materiala saturated aqueous sodium chloride solution, and dried over anhydrous magnesium sulfate
6. customAfter evaporation of the solvent
7. customthe residue was recrystallized from ethanol