4-Fluorophenol → HCID 14069823, compound

HRID 1492953Notes

Reaction equation

HRID 1492953 reaction equation
[Cl:1][CH2:2][CH2:3][C:4](Cl)=[O:5].[F:7][C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=1>C(N(CC)CC)C>[CH:10]1[C:11]([O:14][C:4]([CH2:3][CH2:2][Cl:1])=[O:5])=[CH:12][CH:13]=[C:8]([F:7])[CH:9]=1

Participants

4

Reactant 2

HCID 97324-FluorophenolHCID 693643-Chloropropionyl chloride

Product 1

HCID 14069823HCID 14069823, compoundYield 97.8%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineCatalyst

Conditions

Temperature
60 °C

Procedure

3-Chloropropionyl chloride (391.5 g) and 3 drops of triethylamine is added to 4-fluorophenol (308.3 g) under stirring at 60° C. After heating to 100° C. for 1.5 hrs, distillation gives 544.7 g of (I) boiling at 126°-130° C. 10 mm Hg.

Workup

  1. temperatureAfter heating to 100° C. for 1.5 hrs
  2. distillationdistillation

Sources & evidence

ORD record
ord-e56a908b6fb042ee8a5b9bffe6ca680a
Source dataset
uspto-grants-1994_12
Patent number
US05376687

Reaction notes

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