Diisopropylamine → 1-Boc-4-(4-Chloroquinazolin-6-ylethynyl)piperidine

HRID 149298Notes

Reaction equation

HRID 149298 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([C:14]#[CH:15])[CH2:12][CH2:13]1.[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH:28]([NH:29][CH:30]([CH3:31])[CH3:32])([CH3:33])[CH3:34].[Cl:16][c:17]1[n:18][cH:19][n:20][c:21]2[cH:22][cH:23][c:24]([I:27])[cH:25][c:26]12.[Cu:40][I:41]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([C:14]#[C:15][c:24]2[cH:23][cH:22][c:21]3[n:20][cH:19][n:18][c:17]([Cl:16])[c:26]3[cH:25]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 111738094-Chloro-6-iodoquinazolineHCID 15550481tert-Butyl 4-ethynylpiperidine-1-carboxylate

Product 1

HCID 155504831-Boc-4-(4-Chloroquinazolin-6-ylethynyl)piperidine

Sources & evidence

ORD record
ord-958a8a5518c44d9889555276636eb513
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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