Water → HCID 178479330, compound

HRID 1492981Notes

Reaction equation

HRID 1492981 reaction equation
[C:1]([NH:3][C:4]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=1)=[NH:5])#[N:2].Cl.[Cl:17][C:18]1[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=1.O>C(OCC)(=O)C>[ClH:14].[Cl:17][C:18]1[CH:24]=[CH:23][C:21]([NH:22][C:1]([NH:3][C:4]([NH:6][CH2:7][C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=2)=[NH:5])=[NH:2])=[CH:20][CH:19]=1

Participants

5

Reactant 3

HCID 962WaterHCID 52843634-Chloroaniline hydrochlorideHCID 178512369HCID 178512369, compound

Product 1

HCID 178479330HCID 178479330, compoundYield 130.2%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 20 g of N1 -cyano-N3 -(3,4-dichlorobenzyl)-guanidine and 13.5 g of 4-chloroaniline hydrochloride, 200 ml of water was added, which was heated and refluxed for 2 hours. When cooled gradually after reaction, crystals was precipiated. After filtering the crystals, by drying the crystals obtained by heat treatment in 200 ml of ethyl acetate, 21.8 g of the captioned compound was obtained.

Workup

  1. temperaturewhich was heated
  2. temperaturerefluxed for 2 hours
  3. temperatureWhen cooled gradually
  4. customafter reaction, crystals
  5. filtrationAfter filtering the crystals
  6. customby drying the crystals
  7. customobtained

Sources & evidence

ORD record
ord-a5a508994e1b4bf1b9d42cae9f016248
Source dataset
uspto-grants-1994_12
Patent number
US05376686

Reaction notes

Loading…