Triethylamine → HCID 14514402, compound

HRID 1493230Notes

Reaction equation

HRID 1493230 reaction equation
[N:1]1([CH:6]([C:10]2[CH:15]=[CH:14][N+:13]([O-])=[CH:12][CH:11]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1.C[Si]([C:21]#[N:22])(C)C.C(N(CC)CC)C>C(#N)C>[N:1]1([CH:6]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([C:21]#[N:22])[CH:11]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 82115Trimethylsilyl cyanideHCID 14514401HCID 14514401, compound

Product 1

HCID 14514402HCID 14514402, compoundYield 89.9%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

0.109 g of 4-[1-(1-imidazolyl)-butyl]pyridine-N-oxide is dissolved in 2 ml of acetonitrile, 0.150 g of trimethylsilyl cyanide and 0.101 g of triethylamine are added to it. The reaction is left for 22 hours at 110° C. The mixture is concentrated by evaporation in a vacuum and then distilled on a bulb tube, boiling point: 210°-220° C./0.035 mbar. 0.102 g of 4-[1-(1-imidazolyl)-butyl]-2-cyanopyridine is obtained as brownish oil.

Workup

  1. concentrationThe mixture is concentrated by evaporation in a vacuum
  2. distillationdistilled on a bulb tube

Sources & evidence

ORD record
ord-57466e7e47e04730ae3a4e2bc128971f
Source dataset
uspto-grants-1991_06
Patent number
US05021434

Reaction notes

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