3-Phenylprop-2-Enal → HCID 9998606, compound

HRID 1493312Notes

Reaction equation

C(=O)C=CC1C=CC=CC=1.C(OCC)(=O)C=C.C(N)(=O)C=C.C1(C(=O)C=C)C=CC=CC=1.C1(=O)CCCC=C1.S[CH2:41][C:42]1[NH:43][C:44](C)=[C:45]([C:62]([O:64][CH2:65][CH3:66])=[O:63])[CH:46]([C:53]2[CH:58]=[CH:57][CH:56]=[C:55]([N+:59]([O-:61])=[O:60])[CH:54]=2)[C:47]=1[C:48]([O:50][CH2:51][CH3:52])=[O:49]>>[C:62]([C:45]1[CH:46]([C:53]2[CH:58]=[CH:57][CH:56]=[C:55]([N+:59]([O-:61])=[O:60])[CH:54]=2)[C:47]([C:48]([O:50][CH2:51][CH3:52])=[O:49])=[C:42]([CH3:41])[NH:43][CH:44]=1)([O:64][CH2:65][CH3:66])=[O:63]

Participants

Reactant 6

HCID 3073-Phenylprop-2-Enal

HCID 6579Acrylamide

HCID 8821Ethyl Acrylate

HCID 130281-Phenyl-2-propen-1-one

HCID 135942-Cyclohexen-1-one

HCID 116758332-Mercaptomethyl-3,5-dicarboetoxy-4-(m-nitrophenyl)-6-methyl-1,4-dihydropyridine

Product 1

HCID 9998606HCID 9998606, compound

Procedure

Using in the procedure of Example 31 an α-β-unsatured-oxo compound selected from: cinnamaldehyde, ethyl acrylate, acrylamide, 1-phenyl-1-oxo-2-propene, 1-(p-imidazol-1-yl)phenyl-1-oxo-2-propene, 2-cyclohexen-1-one and 2-mercaptomethyl-3,5-dicarboethoxy-4-(m-nitrophenyl)-6-methyl-1,4-dihydropyridine, the following 3,5-dicarboethoxy-4-(m-nitrophenyl)-6-methyl-1,4-dihydropyridine are prepared:

Sources & evidence

ORD record: ord-1499ce96b9374f0c85bcf051a5256ca7
Source dataset: uspto-grants-1991_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05021436

Reaction notes

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