HCID 178523918, compound → HCID 178512197, compound

HRID 1493350Notes

Reaction equation

HRID 1493350 reaction equation
C([NH:9][C:10]([NH:22][CH2:23][CH2:24][CH2:25][C:26]1[N:27]=[CH:28][NH:29][CH:30]=1)=[N:11][CH2:12][CH2:13][CH2:14][S:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=1)(=O)C1C=CC=CC=1>Cl>[NH:29]1[CH:30]=[C:26]([CH2:25][CH2:24][CH2:23][NH:22][C:10]([NH:11][CH2:12][CH2:13][CH2:14][S:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)=[NH:9])[N:27]=[CH:28]1

Participants

3

Reactant 1

HCID 178523918HCID 178523918, compound

Product 1

HCID 178512197HCID 178512197, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

0.84 g (2 mmol) of N-benzoyl-N'[3-(imidazol-4-yl) propyl]-N"-[3-[(pyrid-2-yl)thio]propyl]-guanidine are heated under reflux in 45 ml of 20% hydrochloric acid for 6 hours. The reaction product is worked up by a method analogous to that of Example 109. It initially precipitates as a dry, hygroscopic foam but this foam gradually crystallises when triturated with acetone and a few drops of ethanol.

Workup

  1. customIt initially precipitates as a dry, hygroscopic foam
  2. customthis foam gradually crystallises when
  3. customtriturated with acetone and a few drops of ethanol

Sources & evidence

ORD record
ord-1ecf25338e714476b5b801ff0bab2c1e
Source dataset
uspto-grants-1991_06
Patent number
US05021431

Reaction notes

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