Acetonitrile → HCID 19768373, compound

HRID 1493402Notes

Reaction equation

HRID 1493402 reaction equation
[CH2:1]([NH2:5])[CH2:2][CH2:3][CH3:4].[CH3:6][CH:7]([O:14][N:15]1[C:20]([CH3:22])([CH3:21])[CH2:19][C:18](=O)[CH2:17][C:16]1([CH3:25])[CH3:24])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C(#N)C.O1CCCC1>CCOCC.C1(C)C=CC=CC=1>[CH2:1]([NH:5][CH:18]1[CH2:19][C:20]([CH3:22])([CH3:21])[N:15]([O:14][CH:7]([CH3:6])[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:16]([CH3:24])([CH3:25])[CH2:17]1)[CH2:2][CH2:3][CH3:4]

Participants

7

Reactant 4

HCID 6342AcetonitrileHCID 8007ButylamineHCID 8028TetrahydrofuranHCID 179683592,2,6,6-Tetramethyl-1-(1-phenylethoxy)piperidin-4-one

Product 1

HCID 19768373HCID 19768373, compoundYield 74%

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared in 74% yield as a colorless syrup from n-butylamine and 1-alpha-methylbenzyloxy-2, 2,6,6-tetramethylpiperidin-4-one (made in Example 11A) according to the procedure of Example 11B. Acetonitrile is substituted for tetrahydrofuran as the reaction solvent and toluene is substituted for ether in the isolation steps.

Sources & evidence

ORD record
ord-236d4919ed3c4ee795f2d851af292112
Source dataset
uspto-grants-1991_06
Patent number
US05021481

Reaction notes

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