HCID 54691271, compound → HCID 11989638, compound

HRID 1493574Notes

Reaction equation

HRID 1493574 reaction equation
O[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12]C)=[CH:9][CH:10]=2)[NH:5][C:4](=[O:14])[C:3]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[O:21]C>Br>[OH:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]3[O:21][C:16]4[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=4[C:3]=3[C:4](=[O:14])[NH:5]2)=[CH:10][CH:9]=1

Participants

3

Reactant 1

HCID 54691271HCID 54691271, compound

Product 1

HCID 11989638HCID 11989638, compoundYield 82.8%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

In 640 ml of 47% hydrobromic acid was suspended 8.0 g of 4-hydroxy-7-methoxy-3-(2-methoxyphenyl)-2quinolone, and the suspension was heated under reflux for 3-4 days. After cooling, the precipitates were collected by filtration, washed with water, and dried to obtain 5.6 g of 3-hydroxy-5H-benzofuro[3,2-c]quinolin-6-one.

Workup

  1. temperaturethe suspension was heated
  2. temperatureunder reflux for 3-4 days
  3. temperatureAfter cooling
  4. filtrationthe precipitates were collected by filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-a161cf8d366d456ab7ded4d793295a62
Source dataset
uspto-grants-1991_06
Patent number
US05023261

Reaction notes

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