Triethylamine → HCID 14819620, compound

HRID 1493576Notes

Reaction equation

HRID 1493576 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]3[O:15][C:14]4[CH:16]=[C:17]([OH:20])[CH:18]=[CH:19][C:13]=4[C:7]=3[C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:28][S:29](Cl)(=[O:31])=[O:30].CN(C1C=CC=CN=1)C>CN(C)C=O.O>[CH3:28][S:29]([O:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]3[O:15][C:14]4[CH:16]=[C:17]([O:20][S:29]([CH3:28])(=[O:31])=[O:30])[CH:18]=[CH:19][C:13]=4[C:7]=3[C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1)(=[O:31])=[O:30]

Participants

7

Reactant 4

HCID 8471TriethylamineHCID 218852-DimethylaminopyridineHCID 31297Methanesulfonyl chlorideHCID 10061491HCID 10061491, compound

Product 1

HCID 14819620HCID 14819620, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

In dry N,N-dimethylformamide was dissolved 500 mg of 3,9-dihydroxy-5H-benzofuro[3,2-c]quinolin-6-one. To the solution were added successively 1.3 ml of triethylamine, 0.72 ml of methylsulfonyl chloride and 10 mg of -dimethylaminopyridine, and the mixture was stirred overnight at room temperature. The reaction mixture was diluted with water, and the precipitates were collected by filtration, washed with water and ether, and dried to obtain 725 mg of 3,9-bis(methylsulfonyloxy)-5H-benzofuro[3,2-c]quinolin-6-one.

Workup

  1. filtrationthe precipitates were collected by filtration
  2. washwashed with water and ether
  3. customdried

Sources & evidence

ORD record
ord-3dcbdeb75c9642309d6767d7435885f9
Source dataset
uspto-grants-1991_06
Patent number
US05023261

Reaction notes

Loading…