Potassium Iodide → 1-[(4-Methoxyphenyl)Methoxy]-3-nitro-Benzene

HRID 1493640Notes

Reaction equation

HRID 1493640 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].[I-].[K+].[CH3:19][O:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25]Cl)=[CH:23][CH:22]=1>CC(C)=O>[CH3:19][O:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25][O:10][C:6]2[CH:5]=[C:4]([N+:1]([O-:3])=[O:2])[CH:9]=[CH:8][CH:7]=2)=[CH:23][CH:22]=1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 111373-NitrophenolHCID 11430Potassium CarbonateHCID 699934-Methyloxybenzyl chloride

Product 1

HCID 36283881-[(4-Methoxyphenyl)Methoxy]-3-nitro-Benzene

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 3-nitrophenol (18.49 g, 0.133 mol), anhydrous potassium carbonate (19.2 g, 0.139 mol), potassium iodide (21.0 g, 0.127 mol) and 4-methoxybenzyl chloride (19.82 g, 0.127 mol) in acetone (200 ml) was heated under reflux for 48 h.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 48 h.

Sources & evidence

ORD record
ord-837abdd7a1da4fada29afe4bd91f6281
Source dataset
uspto-grants-1991_06
Patent number
US05023255

Reaction notes

Loading…