4-Chlorophenol → 4-Chlorophenyl methylsulfamate

A solution of 18.1 g (0.14 mole) of N-methylsulfamoyl chloride (Example 2, pt. a) in 20 ml methylene chloride was added at 10°-20° C. to a solution of 12.8 g (0.10 mole) of 4-chlorophenol and 15 g (0.15 mole) of triethylamine in 50 ml of methylene chloride. The cooling was removed and the mixture stirred at ambient temperature for four hours. The mixture was filtered to remove the triethylamine hydrochloride. The filtrate was extracted with dilute HCl (6 ml of 37% hydrochloric acid in 60 ml water) followed by a water wash. The organic layer was then extracted with dilute potassium carbonate (8.0 g in 80 ml water) followed by a water wash. The methylene chloride layer was concentrated to 21.7 g of yellow oil which crystallized on cooling. The solid was stirred in a mixture of 10 ml toluene and 63 ml petroleum ether to obtain 20.3 g of yellow solid. The 20.3 g was recrystallized from 1:2 toluene: petroleum ether to give 8.73 g of white solid, mp 61°-62° C.

1. customThe cooling was removed
2. filtrationThe mixture was filtered
3. customto remove the triethylamine hydrochloride
4. extractionThe filtrate was extracted with dilute HCl (6 ml of 37% hydrochloric acid in 60 ml water)
5. washwash
6. extractionThe organic layer was then extracted with dilute potassium carbonate (8.0 g in 80 ml water)
7. washwash
8. concentrationThe methylene chloride layer was concentrated to 21.7 g of yellow oil which
9. customcrystallized
10. temperatureon cooling
11. stirringThe solid was stirred in a mixture of 10 ml toluene and 63 ml petroleum ether

ORD record

ord-a57bbe3319ea4a8c8a1a74016c55db76

Source dataset

uspto-grants-1991_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05025031