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HRID1494101

反应详情

EQUATION

反应方程式

HRID 1494101 的结构方程式

REACTANTS

反应物

4
结构：Oc1cccnc1
HCID7971

3-Pyridinol

C5H5NO

结构：c1ccc(P(c2ccccc2)c2ccccc2)cc1
HCID11776

Triphenylphosphine

C18H15P

结构：CCOC(=O)N=NC(=O)OCC
HCID220568

Diethyl azodicarboxylate

C6H10N2O4

结构：COC(=O)CCC(CCO)CCCCNS(=O)(=O)c1ccc(Cl)cc1
HCID10069054

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCOc1cccnc1
HCID10027654

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of 1.2 g of methyl 8-(p-chlorophenylsulfonamido)-4-(2-hydroxyethyl)octanoate in 12 mL methylene chloride is added 1.14 g triphenylphosphine followed by 0.336 g 3-hydroxypyridine. After stirring for 5 minutes, 0.55 mL diethyl azodicarboxylate is added slowly. After 1 hour, solvent is evaporated and the residue subjected to flash chromatography to obtain methyl 8-(p-chlorophenylsulfonamido)-4-[2-(3-pyridyloxy)ethyl]octanoate, m.p. 57-58°.

WORKUP

后处理

  1. waitAfter 1 hour
  2. customsolvent is evaporated