Hydrochloric Acid → HCID 19827789, compound

HRID 1494330Notes

Reaction equation

HRID 1494330 reaction equation
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][C:8]([N+:12]([O-])=O)=[CH:9][CH:10]=2)[NH:5][C:4](=[O:15])[C:3]1=[O:16].[ClH:17]>CN(C)C=O>[ClH:17].[NH2:12][C:8]1[CH:7]=[C:6]2[C:11](=[CH:10][CH:9]=1)[N:2]([CH3:1])[C:3](=[O:16])[C:4](=[O:15])[NH:5]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 37996491-Methyl-6-nitro-1,4-dihydroquinoxaline-2,3-dione

Product 1

HCID 19827789HCID 19827789, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 0.5 g (2.3 mmol) 1-methyl-6-nitroquinoxaline-2,3(1H,4H)-dione in 25 ml dimethylformamide was hydrogenated at atm. pressure by using 5% Pd-c (0.1 g) as a catalyst. The reaction mixture was added 1 ml 4N hydrochloric acid, filtered and evaporated in vacuo. The residue was stirred with ethyl acetate. The precipitate was filtered off to give 0.5 g (98%) of 6-amino-1-methyl-quinoxaline-2,3(1H,4H)-dione hydrochloride. NMR (DMSO-d6 +D2O): 7.3 (1H, d), 7.13 (1H, s), 7.1 (1H, d), 3.5 (3H, s), 2.6 (3H, s).

Workup

  1. filtrationfiltered
  2. customevaporated in vacuo
  3. filtrationThe precipitate was filtered off

Sources & evidence

ORD record
ord-bff2980022894c3b88c5f69750deba41
Source dataset
uspto-grants-1991_06
Patent number
US05026704

Reaction notes

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