Water → HCID 54143264, compound

HRID 1494382Notes

Reaction equation

HRID 1494382 reaction equation
[C:1]1(=[O:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[CH3:12][N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1.[C:19]1(C)C=CC(S(O)(=O)=O)=CC=1.O>C1(C)C=CC=CC=1>[CH3:12][N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH:14]1[C:8]1[CH2:7][CH2:6][C:5]2[C:10]([CH:9]=1)=[C:1]([O:11][CH3:19])[CH:2]=[CH:3][CH:4]=2

Participants

6

Reactant 4

HCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 107241-TetraloneHCID 531671-Methylpiperazine

Product 1

HCID 54143264HCID 54143264, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The tetralone (10 g; 56.8 mmol) was dissolved in 200 ml of toluene. To the solution then were added 13.0 ml (0.117 mol) of N-methylpiperazine followed by 25.1 g (0.13 mol) of p-toluenesulfonic acid. The mixture was stirred at reflux with constant removal of water. After 2 hours, the mixture was cooled to room temperature, and the volatiles were removed in vacuo to give 3-(N-methylpiperazinyl)-5-methoxy-1,2-dihydronaphthalene as a reddish-orange sludge.

Workup

  1. customthe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-3f7d6b4066bb4c0a8227bc7207cfbcf6
Source dataset
uspto-grants-1991_06
Patent number
US05026707

Reaction notes

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