Methyl Thioglycolate → HCID 19828252, compound

HRID 1494440Notes

Reaction equation

HRID 1494440 reaction equation
[CH2:1]([O:9][N:10]1[C:15]([CH3:17])([CH3:16])[CH2:14][CH:13]([OH:18])[CH2:12][C:11]1([CH3:20])[CH3:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[C:21](OC)(=[O:24])[CH2:22][SH:23].[NH2-].[Li+]>C1(C)C=CC=CC=1>[C:21]([O:18][CH:13]1[CH2:14][C:15]([CH3:17])([CH3:16])[N:10]([O:9][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[C:11]([CH3:19])([CH3:20])[CH2:12]1)(=[O:24])[CH2:22][SH:23]

Participants

5

Reactant 3

HCID 16907Methyl ThioglycolateHCID 24532Lithium amideHCID 113466831-Octyloxy-2,2,6,6-tetramethylpiperidin-4-ol

Product 1

HCID 19828252HCID 19828252, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The general procedure of Example 1 is followed using 2.09 grams (7.0 mmol) of 1-octyloxy-4-hydroxy-2,2,6,6-tetramethylpiperidine, 0.74 gram (7.0 mmol) of methyl thioglycolate and 0.17 gram of lithium amide in 50 ml of toluene to afford the title compound after purification by silica gel chromatography.

Sources & evidence

ORD record
ord-171fc11990b641149d2146fa52b16df9
Source dataset
uspto-grants-1991_06
Patent number
US05026750

Reaction notes

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