HRID1494748

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81184

1,8-Diazabicyclo[5.4.0]undec-7-ene

C9H16N2

结构：O=C(O)c1cn(C2CC2)c2c(F)c(F)c(F)cc2c1=O

HCID535414

1-CYCLOPROPYL-6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID

C13H8F3NO3

HCID14795870

4-Bromo-2,3-dihydro-1H-isoindole

C8H8BrN

PRODUCTS

生成物

结构：O=C(O)c1cn(C2CC2)c2c(F)c(N3Cc4cccc(Br)c4C3)c(F)cc2c1=O

HCID14795770

未命名化合物

收率 18.6%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

142 mg of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic acid, 149 mg of 4-bromoisoindoline, 114 mg of DBU, and 1.5 ml of anhydrous DMF were processed in the same manner as in Example 20 to produce 43 mg of the target compound.