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HRID1494759

反应详情

EQUATION

反应方程式

HRID 1494759 的结构方程式

REACTANTS

反应物

3
结构：C1CCC2=NCCCN2CC1
HCID81184

1,8-Diazabicyclo[5.4.0]undec-7-ene

C9H16N2

结构：Nc1c(F)c(F)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1
HCID13910947

5-Amino-1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

C13H9F3N2O3

结构：Fc1cccc2c1CNC2
HCID14795867

4-Fluoro-2,3-dihydro-1H-isoindole

C8H8FN

PRODUCTS

生成物

1
结构：Nc1c(F)c(N2Cc3cccc(F)c3C2)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1
HCID14795776

未命名化合物

收率 21.2%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

200 mg of 1-cyclopropyl-5-amino-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 101 mg of 4-fluoroisoindoline, 200 mg of DBU, and 1.5 ml of anhydrous DMF were processed in the same manner as in Example 20 to produce 59 mg of the target compound.