1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 14795784, compound

HRID 1494767Notes

Reaction equation

HRID 1494767 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[C:9]([F:17])[C:10]([F:16])=[C:11](F)[C:12]=3[F:14])[C:7](=[O:18])[C:6]([C:19]([OH:21])=[O:20])=[CH:5]2)[CH2:3][CH2:2]1.[F:22]C1C2C(=CC=CC=2)CN1.[CH2:32]1[CH2:42][CH2:41][N:40]2C(=N[CH2:37][CH2:38][CH2:39]2)[CH2:34][CH2:33]1>CN(C=O)C>[F:22][C:32]1[CH:33]=[CH:34][CH:37]=[C:38]2[C:42]=1[CH2:41][N:40]([C:11]1[C:12]([F:14])=[C:13]3[C:8]([C:7](=[O:18])[C:6]([C:19]([OH:21])=[O:20])=[CH:5][N:4]3[CH:1]3[CH2:2][CH2:3]3)=[C:9]([F:17])[C:10]=1[F:16])[CH2:39]2

Participants

5

Reactant 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 138255151-Cyclopropyl-5,6,7,8-tetrafluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acidHCID 18354733HCID 18354733, compound

Product 1

HCID 14795784HCID 14795784, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

210 mg of 1-cyclopropyl-5,6,7,8-tetrafluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 106 mg of 40 fluoroisoindoline, 213 mg of DBU, and 1.5 ml of anhydrous DMF were processed in the same manner as in Example 20 to produce 35 mg of the target compound.

Sources & evidence

ORD record
ord-39ade62f6653472d90e9f418625123d6
Source dataset
uspto-grants-1991_06
Patent number
US05026856

Reaction notes

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