1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 14795834, compound

HRID 1494793Notes

Reaction equation

HRID 1494793 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:18]2[C:13](=[CH:14][C:15]([F:21])=[C:16](F)[C:17]=2[F:19])[C:12](=[O:22])[C:11]([C:23]([OH:25])=[O:24])=[CH:10]1.[CH3:26][O:27][C:28]1[CH:36]=[CH:35][CH:34]=[C:33]2[C:29]=1[CH2:30][NH:31][CH2:32]2.C1CCN2C(=NCCC2)CC1>CN(C=O)C>[CH3:26][O:27][C:28]1[CH:36]=[CH:35][CH:34]=[C:33]2[C:29]=1[CH2:30][N:31]([C:7]1[C:2]([F:1])=[C:3]3[C:4]([C:12](=[O:22])[C:11]([C:23]([OH:25])=[O:24])=[CH:10][N:9]3[C:18]3[CH:13]=[CH:14][C:15]([F:21])=[CH:16][C:17]=3[F:19])=[CH:5][C:6]=1[F:8])[CH2:32]2

Participants

5

Reactant 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 14476011HCID 14476011, compoundHCID 147958644-methoxy-2,3-dihydro-1H-isoindole

Product 1

HCID 14795834HCID 14795834, compoundYield 30.9%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

178 mg of 1-(2,4-difluorophenyl)-6,7,8-trifluoro-1,4- dihydro-4-oxoquinoline-3-carboxylic acid, 90 mg of 4-methoxyisoindoline, 137 mg of DBU, and 1.5 ml of anhydrous DMF were processed in the same manner as in Example 20 to produce 75 mg of the target compound.

Sources & evidence

ORD record
ord-2fed66dfbadb4c6989bf9a157b45bb12
Source dataset
uspto-grants-1991_06
Patent number
US05026856

Reaction notes

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