HRID1494807

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81184

1,8-Diazabicyclo[5.4.0]undec-7-ene

C9H16N2

结构：Nc1c(F)c(F)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1

HCID13910947

5-Amino-1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

C13H9F3N2O3

HCID19828510

(2,3-Dihydro-1H-isoindol-4-yl)methanol

C9H11NO

PRODUCTS

生成物

结构：Nc1c(F)c(N2Cc3cccc(CO)c3C2)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1

HCID14795799

未命名化合物

收率 58.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

298 mg of 1-cyclopropyl-5-amino-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 179 mg of 4-hydroxymethylisoindoline, 304 mg of DBU, and 2 ml of anhydrous DMF were processed in the same manner as in Example 20 to produce 250 mg of the target compound.