Fluoren-9-ol → 5-[7-(9H-fluoren-9-yloxy)heptyl]-3-methyl-isoxazole

HRID 1494857Notes

Reaction equation

HRID 1494857 reaction equation
[Na].[OH:2][CH:3]1[C:15]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:9]2[C:4]1=[CH:5][CH:6]=[CH:7][CH:8]=2.[CH3:16][C:17]1[CH:21]=[C:20]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]Br)[O:19][N:18]=1>C1C=CC=CC=1>[CH:14]1[C:15]2[CH:3]([O:2][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][C:20]3[O:19][N:18]=[C:17]([CH3:16])[CH:21]=3)[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[C:10]=2[CH:11]=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 74318Fluoren-9-olHCID 5360545Sodium2×HCID 133169675-(7-Bromoheptyl)-3-methylisoxazole

Product 1

HCID 52727615-[7-(9H-fluoren-9-yloxy)heptyl]-3-methyl-isoxazole

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The sodium salt of 9-hydroxyfluorene was made by reacting sodium metal in anhydrous benzene before the etherization with 7-(3-methylisoxazol-5-yl)-heptyl bromide in the same solvent.

Sources & evidence

ORD record
ord-8ef4b7c73bb247dbb519a70e9aaa115f
Source dataset
uspto-grants-1991_06
Patent number
US05026848

Reaction notes

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