Dimethylformamide → HCID 117628137, compound

HRID 1496640Notes

Reaction equation

HRID 1496640 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=[C:11]([CH2:13][C:14](O)=[O:15])[N:10]([CH2:17][CH3:18])[N:9]=2)=[CH:4][CH:3]=1.CN(C=O)C.C(Cl)(=O)C([Cl:27])=O>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=[C:11]([CH2:13][C:14]([Cl:27])=[O:15])[N:10]([CH2:17][CH3:18])[N:9]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 71255036HCID 71255036, compound

Product 1

HCID 117628137HCID 117628137, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

1.2 mmol (318 mg) of [3-(4-chlorophenyl)-1-ethyl-1H-1,2,4-triazol-5-yl]acetic acid and 0.1 mmol (7 mg) of DMF are dissolved in 5 ml of anhydrous dichloromethane 1.3 mmol of oxalyl chloride (163 mg) in 3 ml of anhydrous dichloromethane are added dropwise. The solution is stirred at room temperature for 8 h and then concentrated under reduced pressure. The [3-(4-chlorophenyl)-1-ethyl-1H-1,2,4-triazol-5-yl]acetyl chloride obtained in this manner is processed further in crude form.

Workup

  1. additionare added dropwise
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-3c6fb5aa64a04031be8f901393fca0da
Source dataset
uspto-grants-2015_12
Patent number
US09198432B2

Reaction notes

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