反应详情

温度

110 °C

50 mg of Example 27 and 9 mg of copper (I) iodide were suspended in 300 μL dioxane under argon. 9.6 μL N,N′dimethylethylendiamine and 45 mg of sodium iodide were added and the mixture heated to 110° C. over weekend. The mixture was diluted with DCM and extracted with aqueous ammonia and water, the organic phase was subsequently concentrated in vacuo and the residual purified with HPLC (XbridgeC18; MeOH/water, TFA) to yield 15 mg yellow solid as Example 37.

1. extractionextracted with aqueous ammonia and water
2. concentrationthe organic phase was subsequently concentrated in vacuo
3. customthe residual purified with HPLC (XbridgeC18; MeOH/water, TFA)