Potassium Carbonate → HCID 118105736, compound

HRID 1496951Notes

Reaction equation

HRID 1496951 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][CH:12]([CH3:14])[CH3:13])[CH:3]=1.[C:15]([N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)(=[O:17])[CH3:16].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH:12]([O:11][C:4]1[CH:3]=[C:2]([N:21]2[CH2:22][CH2:23][N:18]([C:15](=[O:17])[CH3:16])[CH2:19][CH2:20]2)[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9])([CH3:14])[CH3:13]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 837951-AcetylpiperazineHCID 106318324-Fluoro-2-isopropoxy-1-nitrobenzene

Product 1

HCID 118105736HCID 118105736, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound obtained in Step 1 above (300 mg), N-acetylpiperazine (300 mg), and potassium carbonate (500 mg) were dissolved in dimethylformamide (3 mL) and reacted at 80° C. overnight. The dimethylformamide of the reaction mixture was removed under reduced pressure, and added with water to form a solid. The solid was filtered to obtain a target compound as a yellow solid.

Workup

  1. customreacted at 80° C. overnight
  2. customThe dimethylformamide of the reaction mixture was removed under reduced pressure
  3. additionadded with water
  4. customto form a solid
  5. filtrationThe solid was filtered

Sources & evidence

ORD record
ord-f2c81c3428fe438fb29a1406e28af639
Source dataset
uspto-grants-2015_12
Patent number
US09199944B2

Reaction notes

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