Potassium Carbonate → HCID 90383149, compound

HRID 1496956Notes

Reaction equation

HRID 1496956 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](F)[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[C:12]([N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)(=[O:14])[CH3:13].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:1][C:2]1[CH:7]=[C:6]([N:18]2[CH2:19][CH2:20][N:15]([C:12](=[O:14])[CH3:13])[CH2:16][CH2:17]2)[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 750172-Chloro-4-fluoro-1-nitrobenzeneHCID 837951-Acetylpiperazine

Product 1

HCID 90383149HCID 90383149, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
50 °C

Procedure

2-chloro-4-fluoronitrobenzene (350 mg), N-acetylpiperazine (0.5 ml) and potassium carbonate (500 mg) were dissolved in dimethylformamide (3 ml) and stirred at 50° C. overnight. The reaction mixture was distilled under reduced pressure to remove dimethylformamide and added with distilled water. Then, the recrystallized yellow solid was filtered and the subsequent reaction was proceeded without further purification.

Workup

  1. distillationThe reaction mixture was distilled under reduced pressure
  2. customto remove dimethylformamide
  3. additionadded with distilled water
  4. filtrationThen, the recrystallized yellow solid was filtered
  5. customthe subsequent reaction
  6. customwas proceeded without further purification

Sources & evidence

ORD record
ord-6d2d80ced1344d0da5a4f7a2daeca31c
Source dataset
uspto-grants-2015_12
Patent number
US09199944B2

Reaction notes

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