Water → HCID 53269422, compound

HRID 1496967Notes

Reaction equation

HRID 1496967 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4](F)[CH:3]=1.[C:12]([NH2:16])([CH3:15])([CH3:14])[CH3:13].O>CS(C)=O>[C:12]([NH:16][C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9])([CH3:15])([CH3:14])[CH3:13]

Participants

5

Reactant 3

HCID 962WaterHCID 6385Tert-ButylamineHCID 696914-Chloro-2-fluoro-1-nitrobenzene

Product 1

HCID 53269422HCID 53269422, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

4-chloro-2-fluoronitrobenzene (250 mg) and t-butylamine (0.40 mL) were dissolved in dimethyl sulfoxide (3.0 mL) and stirred at room temperature overnight. Then, the mixture was added with water and extracted with ethyl acetate. The thus obtained organic layer was washed with saturated brine, and the water was removed with sodium sulfate, and the solvent was removed by distillation under reduced pressure. The subsequent reaction was proceeded without further purification of the thus obtained compound.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe thus obtained organic layer was washed with saturated brine
  3. customthe water was removed with sodium sulfate
  4. customthe solvent was removed by distillation under reduced pressure
  5. customThe subsequent reaction
  6. customwas proceeded without further purification of the thus obtained compound

Sources & evidence

ORD record
ord-f72383f17c5045168e8a3a546fed3716
Source dataset
uspto-grants-2015_12
Patent number
US09199944B2

Reaction notes

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