Nitrogen → HCID 86682927, compound

HRID 1497048Notes

Reaction equation

HRID 1497048 reaction equation
C(OC(=O)C)(=O)C.[Cl:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]=[C:14]([C:19]([OH:21])=[O:20])[C:13]([C:22]([OH:24])=O)=[C:12]2[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.N#N.N1C=CC=CC=1>C(COC)OC>[Cl:8][C:9]1[CH:18]=[CH:17][C:16]2[N:15]=[C:14]3[C:19](=[O:21])[O:20][C:22](=[O:24])[C:13]3=[C:12]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)[C:11]=2[CH:10]=1

Participants

6

Reactant 4

HCID 947NitrogenHCID 1049PyridineHCID 7918Acetic AnhydrideHCID 72947918HCID 72947918, compound

Product 1

HCID 86682927HCID 86682927, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

Acetic anhydride (288 μl, 3.0 mmol) was added to a stirred suspension of 6-chloro-4-phenylquinoline-2,3-dicarboxylic acid (100 mg, 0.31 mmol) in dimethoxyethane (1 ml) in an inert N2 atmosphere followed by the addition of pyridine (49 μl, 0.61 mmol) at room temperature.

Sources & evidence

ORD record
ord-dc9908b1c781484aacda83134385391d
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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