Lithium iodide → HCID 71556488, compound

HRID 1497100Notes

Reaction equation

HRID 1497100 reaction equation
C[O:2][C:3]([C:5]1[C:6]([CH2:22][C:23]([F:26])([F:25])[F:24])=[N:7][C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][C:11]([Cl:21])=[CH:10][CH:9]=2)=[O:4].[I-].[Li+]>N1C=CC=CC=1>[Cl:21][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[N:7]=[C:6]([CH2:22][C:23]([F:26])([F:24])[F:25])[C:5]([C:3]([OH:4])=[O:2])=[C:14]2[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 66321Lithium iodideHCID 86682957HCID 86682957, compound

Product 1

HCID 71556488HCID 71556488, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound was prepared in analogy to example 20 step D from 6-chloro-4-phenyl-2-(2,2,2-trifluoro-ethyl)-quinoline-3-carboxylic acid methyl ester (60 mg, 0.16 mmol) and lithium iodide (212 mg, 1.58 mmol) in pyridine. Off white solid (9.5 mg, 16%). LC-MS: 364 (M−H)−.

Sources & evidence

ORD record
ord-1d1e295d09b248d8a36129868bbd8b8d
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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