Lithium iodide → HCID 71556489, compound

HRID 1497102Notes

Reaction equation

HRID 1497102 reaction equation
C[O:2][C:3]([C:5]1[C:6]([CH:24]([CH3:26])[CH3:25])=[N:7][C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[C:17]([Cl:22])[CH:16]=1)=[CH:12][C:11]([Cl:23])=[CH:10][CH:9]=2)=[O:4].[I-].[Li+]>N1C=CC=CC=1>[Cl:23][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[N:7]=[C:6]([CH:24]([CH3:26])[CH3:25])[C:5]([C:3]([OH:4])=[O:2])=[C:14]2[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[C:17]([Cl:22])[CH:16]=1

Participants

4

Reactant 2

HCID 66321Lithium iodideHCID 86682958HCID 86682958, compound

Product 1

HCID 71556489HCID 71556489, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound was prepared in analogy to example 20 step D from 6-chloro-4-(3-chloro-4-fluoro-phenyl)-2-isopropyl-quinoline-3-carboxylic acid methyl ester (60 mg, 0.15 mmol) and lithium iodide in pyridine. Off white solid (43 mg, 74%). LC-MS: 376 (M−H)−.

Sources & evidence

ORD record
ord-33bb36213eaa4713abda3d5146b09a4c
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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