Lithium iodide → 6-Chloro-2-cyclopentyl-4-phenyl-quinoline-3-carboxylic acid

HRID 1497104Notes

Reaction equation

HRID 1497104 reaction equation
C([O:3][C:4]([C:6]1[C:7]([CH:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)=[N:8][C:9]2[C:14]([C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:13][C:12]([Cl:22])=[CH:11][CH:10]=2)=[O:5])C.[I-].[Li+]>N1C=CC=CC=1>[Cl:22][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH:23]1[CH2:24][CH2:25][CH2:26][CH2:27]1)[C:6]([C:4]([OH:5])=[O:3])=[C:15]2[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 66321Lithium iodideHCID 86682959HCID 86682959, compound

Product 1

HCID 715564906-Chloro-2-cyclopentyl-4-phenyl-quinoline-3-carboxylic acid

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound was prepared in analogy to example 20 step D from 6-chloro-2-cyclopentyl-4-phenyl-quinoline-3-carboxylic acid ethyl ester (35 mg, 0.09 mmol) and lithium iodide in pyridine. Off-white solid (15 mg, 46%). LC-MS: 350 (M−H)−.

Sources & evidence

ORD record
ord-41605986830d420f90f8e73b090324c7
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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