Lithium iodide → HCID 71556492, compound

HRID 1497108Notes

Reaction equation

HRID 1497108 reaction equation
C([O:3][C:4]([C:6]1[C:7]([N:23]2[CH2:27][CH2:26][CH2:25][C:24]2=[O:28])=[N:8][C:9]2[C:14]([C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:13][C:12]([Cl:22])=[CH:11][CH:10]=2)=[O:5])C.[Li+].[I-]>N1C=CC=CC=1>[Cl:22][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:23]1[CH2:27][CH2:26][CH2:25][C:24]1=[O:28])[C:6]([C:4]([OH:5])=[O:3])=[C:15]2[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 66321Lithium iodideHCID 86682961HCID 86682961, compound

Product 1

HCID 71556492HCID 71556492, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound was prepared in analogy to example 20 step D from 6-chloro-2-(2-oxo-pyrrolidin-1-yl)-4-phenyl-quinoline-3-carboxylic acid ethyl ester (50 mg, 0.13 mmol) and LiI in pyridine. Yellow solid (11 mg, 24%). LC-MS: 367 (M+H)+.

Sources & evidence

ORD record
ord-89ea1e1d98cb42b29a7776d08c04bf87
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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