Lithium iodide → HCID 71556551, compound

HRID 1497110Notes

Reaction equation

HRID 1497110 reaction equation
C([O:3][C:4]([C:6]1[C:7]([CH:26]([CH3:28])[CH3:27])=[N:8][C:9]2[C:14]([C:15]=1[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[O:23][CH3:24])=[CH:13][C:12]([Cl:25])=[CH:11][CH:10]=2)=[O:5])C.[I-].[Li+]>N1C=CC=CC=1>[Cl:25][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH:26]([CH3:28])[CH3:27])[C:6]([C:4]([OH:5])=[O:3])=[C:15]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[O:23][CH3:24]

Participants

4

Reactant 2

HCID 66321Lithium iodideHCID 86682962HCID 86682962, compound

Product 1

HCID 71556551HCID 71556551, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound was prepared in analogy to example 20 step D from 6-chloro-2-isopropyl-4-(2-methoxy-benzyl)-quinoline-3-carboxylic acid ethyl ester (80 mg, 0.2 mmol) and lithium iodide (134.5 mg, 1.01 mmol) in pyridine. Off white solid (24 mg, 32%). LC-MS (ESI): 368 (M−H)−.

Sources & evidence

ORD record
ord-17ce773f22ea423fbb065a4958ed2725
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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