Lithium iodide → HCID 71556621, compound

HRID 1497128Notes

Reaction equation

HRID 1497128 reaction equation
C([O:3][C:4]([C:6]1[C:7]([N:23]([CH2:26][CH3:27])[CH2:24][CH3:25])=[N:8][C:9]2[C:14]([C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:13][C:12]([Cl:22])=[CH:11][CH:10]=2)=[O:5])C.[Li+].[I-]>N1C=CC=CC=1>[Cl:22][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:23]([CH2:26][CH3:27])[CH2:24][CH3:25])[C:6]([C:4]([OH:5])=[O:3])=[C:15]2[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 66321Lithium iodideHCID 86682972HCID 86682972, compound

Product 1

HCID 71556621HCID 71556621, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound was prepared in analogy to example 20 step D from 6-chloro-2-diethylamino-4-phenyl-quinoline-3-carboxylic acid ethyl ester (50 mg, 0.13 mmol) and LiI in pyridine. Pale yellow solid (30 mg, 65%). LC-MS: 355 (M+H)+.

Sources & evidence

ORD record
ord-0467f4dcbc8743018f7cb4b3001d6671
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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