Lithium iodide → HCID 71556622, compound

HRID 1497130Notes

Reaction equation

HRID 1497130 reaction equation
C([O:3][C:4]([C:6]1[C:7]([O:23][CH:24]([CH3:29])[C:25]([F:28])([F:27])[F:26])=[N:8][C:9]2[C:14]([C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:13][C:12]([Cl:22])=[CH:11][CH:10]=2)=[O:5])C.[Li+].[I-]>N1C=CC=CC=1>[Cl:22][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:23][CH:24]([CH3:29])[C:25]([F:28])([F:26])[F:27])[C:6]([C:4]([OH:5])=[O:3])=[C:15]2[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 66321Lithium iodideHCID 86682973HCID 86682973, compound

Product 1

HCID 71556622HCID 71556622, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound was prepared in analogy to example 20 step D from 6-chloro-4-phenyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-quinoline-3-carboxylic acid ethyl ester (100 mg, 0.26 mmol) and LiI in pyridine. Off white solid (55 mg, 53%). LC-MS: 396 (M+H)+.

Sources & evidence

ORD record
ord-31bda599fa574ab1a15752b6ce3eba30
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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