Ethyl Acetate → HCID 86682981, compound

HRID 1497140Notes

Reaction equation

HRID 1497140 reaction equation
[Cl:1][C:2]1[CH:8]=[C:7](I)[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=1.[Cl:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]#[CH:19].C(OCC)(=O)C>CCCCCCC>[Cl:1][C:2]1[CH:3]=[C:4]([F:10])[C:5]([NH2:6])=[C:7]([C:19]#[C:18][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[Cl:11])[CH:8]=1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 5859951-Chloro-2-ethynylbenzeneHCID 27736504-Chloro-2-fluoro-6-iodoaniline

Product 1

HCID 86682981HCID 86682981, compound

Reagents, catalysts & solvents 1

HCID 8900HeptaneSolvent

Procedure

The title compound was prepared in analogy to example 10 step A from 4-chloro-2-fluoro-6-iodoaniline (500 mg, 1.84 mmol) and 1-chloro-2-ethynyl-benzene (302 mg, 2.21 mmol). Brown solid (1.05 g, 68%). Rf 0.3 (1:9 Ethyl acetate:heptane) as a bright blue spot under UV light.

Sources & evidence

ORD record
ord-62f319d7c2a54ef0894cd890aa2a2782
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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