Lithium iodide → HCID 71556818, compound

HRID 1497152Notes

Reaction equation

HRID 1497152 reaction equation
C([O:3][C:4]([C:6]1[C:7]([CH2:25][C:26]([F:29])([F:28])[F:27])=[N:8][C:9]2[C:14]([C:15]=1[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23])=[CH:13][C:12]([Cl:24])=[CH:11][CH:10]=2)=[O:5])C.[Li+].[I-]>N1C=CC=CC=1>[Cl:24][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH2:25][C:26]([F:29])([F:27])[F:28])[C:6]([C:4]([OH:5])=[O:3])=[C:15]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23]

Participants

4

Reactant 2

HCID 66321Lithium iodideHCID 86682990HCID 86682990, compound

Product 1

HCID 71556818HCID 71556818, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound was prepared in analogy to example 20 step D from 6-chloro-4-(2-chloro-benzyl)-2-(2,2,2-trifluoro-ethyl)-quinoline-3-carboxylic acid ethyl ester (70 mg, 0.16 mmol) and LiI (212 mg, 1.58 mmol) in pyridine. Off white solid (15 mg, 23%). LC-MS: 412 (M−H)−.

Sources & evidence

ORD record
ord-19bcc7a14b19473188a9def3821bda69
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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