Hydrochloric Acid → HCID 71556887, compound

HRID 1497180Notes

Reaction equation

HRID 1497180 reaction equation
C([O:5][C:6]([C:8]1[C:9]([N:28]([CH3:30])[CH3:29])=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH:24]([CH3:26])[CH3:25])[CH:19]=1)=[CH:15][C:14]([Cl:27])=[CH:13][CH:12]=2)=[O:7])(C)(C)C.Cl>O1CCOCC1>[Cl:27][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([N:28]([CH3:29])[CH3:30])[C:8]([C:6]([OH:7])=[O:5])=[C:17]2[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH:24]([CH3:26])[CH3:25])[CH:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86683011HCID 86683011, compound

Product 1

HCID 71556887HCID 71556887, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound was prepared in analogy to example 78 step E from 6-chloro-2-dimethylamino-4-(3-isopropyl-phenyl)-quinoline-3-carboxylic acid tert-butyl ester (75 mg, 0.18 mmol) and 4N HCl in dioxane. Off white solid (45 mg, 69%). LC-MS (ESI): 369 (M+H)+.

Sources & evidence

ORD record
ord-0bf42f88f76f44babf7497139a2e8876
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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