Hydrochloric Acid → HCID 86626150, compound

HRID 1497489Notes

Reaction equation

HRID 1497489 reaction equation
[Cl:1][C:2]1[C:3]([C:8]2[CH:13]=[CH:12][C:11]([C:14]3[NH:18][C:17]4[CH:19]=[C:20]([C:23]([F:26])([F:25])[F:24])[CH:21]=[CH:22][C:16]=4[N:15]=3)=[CH:10][CH:9]=2)=[N:4][CH:5]=[CH:6][CH:7]=1.Cl>C(OCC)C>[Cl-:1].[Cl:1][C:2]1[C:3]([C:8]2[CH:13]=[CH:12][C:11]([C:14]3[NH:18][C:17]4[CH:19]=[C:20]([C:23]([F:26])([F:24])[F:25])[CH:21]=[CH:22][C:16]=4[N:15]=3)=[CH:10][CH:9]=2)=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11646459HCID 11646459, compound

Product 1

HCID 86626150HCID 86626150, compoundYield 187.1%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

500 mg (1.34 mmol) of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-1H-benzoimidazole was dissolved in 10 mL of diethylether, followed by stirring for 30 min at a subzero temperature. After saturation with gaseous hydrochloric acid, the solution was stirred for an additional one hour at a subzero temperature. A white precipitate thus obtained was filtered and dried for 24 hours in a vacuum condition to give 513 mg of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-1H-benzoimidazole chloride.

Workup

  1. customA white precipitate thus obtained
  2. filtrationwas filtered
  3. customdried for 24 hours in a vacuum condition

Sources & evidence

ORD record
ord-4e0572980a41487c9c2e0d8ef718e38c
Source dataset
uspto-grants-2015_12
Patent number
US09199965B2

Reaction notes

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