Hydrochloric Acid → HCID 90281947, compound

HRID 1497507Notes

Reaction equation

HRID 1497507 reaction equation
C(OC([NH:8][C@H:9]([C:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=1)=O)(C)(C)C.[ClH:28]>O1CCOCC1>[ClH:28].[F:17][C:13]1[CH:12]=[C:11]([CH:16]=[CH:15][CH:14]=1)[CH2:10][C@@H:9]([C:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19])[NH2:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90281911HCID 90281911, compound

Product 1

HCID 90281947HCID 90281947, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To benzyl N-(tert-butoxycarbonyl)-3-fluoro-L-phenylalaninate (659 mg) was added a 4 M solution of hydrogen chloride in dioxane (8.82 mL), followed by stirring at room temperature overnight. The reaction mixture was concentrated under reduced pressure to obtain benzyl 3-fluoro-L-phenylalaninate hydrochloride (505 mg).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-25b714061e1343d5aef03ffaf1d4e3e6
Source dataset
uspto-grants-2015_12
Patent number
US09199927B2

Reaction notes

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