HCID 86704190, compound → HCID 86704192, compound

HRID 1497652Notes

Reaction equation

HRID 1497652 reaction equation
[C:1]([C:4]1[C:5]([F:25])=[C:6]([N:10]([CH2:22][O:23][CH3:24])[S:11]([C:14]2[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=2[F:21])(=[O:13])=[O:12])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].C1C=C[NH+]=CC=1.[Br:32][Br-]Br>C1COCC1>[Br:32][CH2:2][C:1]([C:4]1[C:5]([F:25])=[C:6]([N:10]([CH2:22][O:23][CH3:24])[S:11]([C:14]2[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=2[F:21])(=[O:13])=[O:12])[CH:7]=[CH:8][CH:9]=1)=[O:3]

Participants

3

Reactant 1

HCID 86704190HCID 86704190, compound

Product 1

HCID 86704192HCID 86704192, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
80 °C

Procedure

100 mg (0.27 mmol) of N-(3-acetyl-2-fluorophenyl)-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide were dissolved in 10 mL of dry THF and 100 mg (0.3 mmol) of pyridinium bromide perbromide were added. The resulting solution was heated in a microwave apparatus at 80° C. for 15 min. The solvent was then evaporated, the residue taken up with DCM and washed with 0.5 N HCl. The organic layer was then dried over Na2SO4 and evaporated to give the title compound as an oil.

Workup

  1. customThe solvent was then evaporated
  2. washwashed with 0.5 N HCl
  3. dry with materialThe organic layer was then dried over Na2SO4
  4. customevaporated

Sources & evidence

ORD record
ord-5892dc8fde9e4bcd8898f25877c44960
Source dataset
uspto-grants-2015_12
Patent number
US09199979B2

Reaction notes

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