Water → HCID 123869272, compound

HRID 1497699Notes

Reaction equation

HRID 1497699 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=O.[CH3:17][C:18]([S:21]([NH2:23])=[O:22])([CH3:20])[CH3:19].O>C1COCC1>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[N:23][S:21]([C:18]([CH3:20])([CH3:19])[CH3:17])=[O:22]

Participants

5

Reactant 3

HCID 962WaterHCID 996772-Amino-5-bromobenzophenoneHCID 3382465Tert-Butanesulfinamide

Product 1

HCID 123869272HCID 123869272, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of (2-Amino-5-bromo-phenyl)-phenyl-methanone (67 g, 244 mmol), 2-Methyl-propane-2-sulfinic acid amide (35.38 g, 292 mmol) and Ti(OEt)4 (111.15 g, 487 mmol) in THF (800 mL) is heated to reflux overnight. Then H2O is added and filtered and concentrated. The residue is purified by chromatography on silica gel to give desired product.

Workup

  1. temperatureto reflux overnight
  2. filtrationfiltered
  3. concentrationconcentrated
  4. customThe residue is purified by chromatography on silica gel

Sources & evidence

ORD record
ord-72c7b8f888d948b1bfb05056b5626bf4
Source dataset
uspto-grants-2015_12
Patent number
US09199988B2

Reaction notes

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